Additionally, the densities of Tregs (Foxp3+) and the ratios of Tregs/T (Foxp3/CD3) and Tregs/Tc (Foxp3/CD8) were also significantly lower in the HR-MDS group (p < 0.001, p < 0.001 and p = 0.001, respectively). The gene discussed is FOXP3; the disease is myelodysplastic syndrome.