CD4 and myelodysplastic syndrome: Lower-risk MDS (LR-MDS) are characterized by a proinflammatory immune response with increased populations of effector T cells, such as CD4+ cells and cytotoxic T cells (Tc) [5,6]; on the other hand, high-risk (HR) MDS show a suppressive immune profile that includes the expansion of immunosuppressive cells like Tregs and myeloid-derived suppressor cells (MDSCs) [7].