The MCF model showed high prediction efficacy in differentiating individuals with OC versus those who did not have OC, with an AUC of 0.949 (CI 95% 0.948–0.950), outperforming CA125 and HE4 alone in identifying ovarian cancer, especially in early-stage ovarian cancer prediction [7]. The gene discussed is WFDC2; the disease is ovarian cancer.