ANXA1 and neoplasm: The potential role of ANXA1 in the tumor microenvironment, investigated through the administration of Ac2-26, which is known as an ANXA1 mimetic peptide, highlighted the slowdown of cell motility and the consequent reversion of the cell aggressive phenotype exclusively in CAL27 cells and confirmed the crucial role of this protein, even as an external actor, but only in cases of poorly differentiated stemlike phenotype.