The Vδ1 TCR specifically binds to MHC-like proteins within the CD1 family, such as CD1c and CD1d, as well as Annexin A2 and stress-induced ligands such as MICA/B and UL16-binding proteins, which are often upregulated in tumor cells [34,41,42,43,44]. The gene discussed is CD1D; the disease is neoplasm.