CD8A and neoplasm: In regard to the spatial distribution of immune cells in the tumor microenvironment, CD8+ T-cells with exhausted phenotype (PD-1+, LAG-3+, TIM-3+) and M2 macrophages (CD68+, CD163+, CD86−) were found co-localized with neoplastic plasma cells with an increasing infiltration from “normal” to tumor areas [12,13].