TSGs can be broadly categorized into several types, including ‘gatekeepers’ (e.g., RB1 and APC) that directly regulate cell growth, ‘caretakers’ (e.g., BRCA1 and ATM) that maintain genomic integrity, and ‘landscapers’ that modulate the tumor microenvironment [e.g., PTEN and TGFβ] [73,74,75]. This evidence concerns the gene RB1 and neoplasm.