To our knowledge, only three studies investigated diagnostic radiation exposure to the chest among women with a hereditary predisposition to BC and almost all without BRCA1/2 pathogenic variant [5,15,21], and only one considered mammograms by assessing the effect of age at first exposure and did not find evidence for an increased BC risk for women exposed before 37 years of age compared to women first exposed between the ages of 40 and 46 years [21]. The gene discussed is BRCA1; the disease is breast cancer.