While exposures to diagnostic ionizing radiation to the chest excluding mammograms have been studied in the population with a genetic predisposition to BC [2,3,4,5,6,7,8], few studies have investigated the effect of mammograms in such populations, and these studies were essentially conducted among BRCA1/2 pathogenic variant carriers [2,4,9,10,11,12,13]. The gene discussed is BRCA1; the disease is breast cancer.