Given the increasing burden of GC in H/L populations and the limited molecular characterization of this disease in this group [7,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34], this study aims to comprehensively analyze pathway-specific alterations in TP53, WNT, PI3K, TGF-Beta, and RTK/RAS signaling in GC. This evidence concerns the gene PIK3CA and gastric cancer.