The OD-BRE-0438 model with the most resistant phenotype, as evidenced by the shortest median PFS, showed statistically significant upregulated gene expression of FGF1, FGF7, and FGF8 ligands in cancer cells, while FGFR1, FGFR2, or FGFR3 were not upregulated (Figure 1b). Here, FGF8 is linked to cancer.