Nonetheless, a recent study has been shown no significant difference between LEP and ADIPQ gene expression in a group of RCC patients compared to a control group [28], while other studies find no significant differences in adiponectin expression of human adipose explants by comparison with normal (hRAN) or kidney cancer (hRAT) cells in conditioned media [20,59]. The gene discussed is LEP; the disease is renal cell carcinoma.