JAG1 and cancer: PRAT also modulates vascular endothelial growth factor A (VEGFA), vascular endothelial growth factor D (VEGFD), Jagged 1 (JAG1), and transforming growth factor β1 (TGF-β1) activity in the tumor niche, promoting tumor angiogenesis and, consequently, cancer cell growth and metastasis [16,17,18].