With this in mind, and due to recently published data on the role of pentamidine in the amelioration of S100B toxic effects on EAE mice (Di Sante et al. 2020; Barros et al. 2022), we investigated whether the reduction of neuroinflammation by depletion of S100B in EAE mice at distinct ages could be an effective therapeutic approach for young- or late-onset MS. Here, S100B is linked to myeloid sarcoma.