PLN and cancer: Risk calculators, indicating the individual risk of malignant ventricular arrhythmias and sudden cardiac death, thereby aiding in clinical decision making on implantable cardioverter-defibrillator (ICD) implantation for primary prevention, exist for HCM and ARVC and gene-specific risk calculators for phospholamban (PLN) and lamin A/C (LMNA) [13, 14].