Such insights are further substantiated by the regulation of genes like 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), which, as a pivotal enzyme in the mevalonate pathway, plays a dual role in both cholesterol synthesis and stress response, underscoring its potential as a pharmacological target in the context of acute myeloid leukemia (AML) chemoresistance [55]. Here, HMGCS1 is linked to acute myeloid leukemia.