Among the differentially expressed genes, the upregulation of Abcb1a, Apoa4, Slc51b, Gpx2, Gsta1, and Hsp90aa1 may be essential for hepatic protection and metabolic homeostasis, while the downregulation of Fkbp5 may help suppress inflammatory responses and slow ALI progression. Here, FKBP5 is linked to acute respiratory distress syndrome.