A recent study reported that EMPA reduced cardiomyocyte hypertrophy and myocardial OS by suppressing advanced oxidation protein product (AOPP) levels and reducing the expression of NADPH oxidase 2 (NOX2) in rats with myocardial infarction (MI) [92], indicating a reduction in myocardial OS. The gene discussed is CYBB; the disease is myocardial infarction.