Interestingly, in type 2 diabetes mellitus (Otsuka Long-Evans Tokushima Fatty-OLETF) rats, CANA treatment was shown to have a renoprotective action via reducing lipid peroxides (MDA + 4HNE) and NOX proteins (NOX2 and NOX4) in the kidneys when combined with fasting before myocardial infarction (MI) [133]. The gene discussed is NOX4; the disease is myocardial infarction.