PRNP and cardiovascular disorder: Besides their roles in normal function, disordered proteins are also involved in numerous serious disorders in humans, such as neurodegenerative (Aβ protein, Tau Protein, prion proteins, a-synuclein) [129], cancer (breast cancer type 1 susceptibility protein (BRCA-1) and p53), cardiovascular disease (thrombin), and diabetes (amylin) [130,131].