A recent study using SLE mouse models, Liu et al. [73], showed Ncf1-/- B cells on the C57BL/6 genetic background exhibited competitive advantage in germinal center (GC) entry, expansion/selection, enhanced humoral responses to TLR-containing viral antigens, and increased class-switched IgM- IgD- B cells. This evidence concerns the gene NCF1 and systemic lupus erythematosus.