Genetic ablation or chemical inhibition of NOX2 resulted in reduced distal metastasis of inoculated melanoma, while NK cell depletion abolished the inhibitory effect of NOX2 deficiency on tumor metastasis, and enhanced IFNγ production was observed from NOX2-deficient NK cells, suggesting NOX2-derived ROS facilitate metastasis of melanoma cells by downmodulating NK cell function [86]. The gene discussed is IFNG; the disease is melanoma.