NFE2L2 and Mental deterioration: Additionally, Lin et al. recently showed that chronic alcohol exposure promoted impairment of both receptor-mediated and PINK1-related mitophagy in the medial prefrontal cortex, leading to elevated NLRP3-related neuroinflammation and cognitive decline in C57BL6/J mice through suppression of an antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (NRf2) [40].