These results suggest that (i) F. nucleatum, in comparison with other microorganisms, could be resistant against the antimicrobial activity of HMOX1, and (ii) the induction of hyperexpression of ALAD, HMXO1, CAT, and SOD could explain the role of this bacterium in promoting tumor drug protection and progression [30,31,54]. The gene discussed is CAT; the disease is neoplasm.