The transcript abundance of the glutamate–cysteine ligase catalytic subunit (Gclc) and glutamate–cysteine ligase regulatory subunit (Gclm), which together form the rate-limiting enzyme in glutathione synthesis, were also enhanced in the STZ-T1D + RH animals (the effect of the Hypo, p < 0.05) and maintained in the presence of the SFN (the effect of the SFN, p < 0.05; Table 1). Here, GCLC is linked to type 1 diabetes mellitus.