Likewise, the mRNA levels for the classical Nrf2 target gene Nqo1 were elevated following the administration of SFN compared to the untreated STZ-T1D or STZ-T1D + RH animals (the effect of the SFN, p < 0.01; Table 1), although Hmox-1 and Sod2 were unaffected by these interventions. This evidence concerns the gene HMOX1 and type 1 diabetes mellitus.