NFE2L2 and type 1 diabetes mellitus: Compared with the STZ-T1D animals, the RH increased the transcript abundance of Nfe212, the gene encoding Nrf2, in the hippocampus (the effect of the Hypo, p < 0.01), an effect also seen with the SFN (the effect of the SFN, p < 0.01) and further augmented in the STZ-T1D + RH + SFN mice (Hypo × SFN, p < 0.01; Table 1).