GPX4 and Charcot-Marie-Tooth disease type 1A: To test this hypothesis, we exposed cultured primary fibroblasts from CMT1A and wild-type (WT) patients to RAS-selective lethal 3 (RSL3), a potent and specific inducer of ferroptosis that inhibits GPX4, and assessed the differences in cell death progression between the groups [32,33,34].