However, restoring the ATF4 level via Ad-ATF4 infection led to decreased levels of GPX4 and phosphorylated mTOR, S6, and 4EBP1 by erastin, suggesting that ATF4 mediates the erastin-induced mTOR inhibition and the subsequent activation of ferroptosis signaling (Figure 4J). The gene discussed is EIF4EBP1; the disease is infection.