Kantner et al. (2013) found in murine models that the fusion gene ETV6/RUNX1 (TEL/AML1), the most common chromosomal aberration in the pediatric form of ALL, which occurs in 25% of children with B-ALL, generates a preleukemic clone and induces elevated levels of ROS. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.