Other players, such as p62 (SQSTM1), which activates tumor-promoting NFκB and Nrf2 pathways [367], and mitophagy receptors BNIP3 and BNIP3L (NIX), which protect against tumorigenesis by maintaining mitochondrial quality [368], further demonstrate the multifaceted role of autophagy in hematological malignancies [369,370,371] and its role in disease prognosis [371]. This evidence concerns the gene NFKB1 and neoplasm.