Additionally, the modulation of pathways such as Akt, mTOR, and tyrosine kinases, as well as other key signaling pathways like Notch, Wnt, and Hedgehog, underscores the complexity and context-dependent roles of autophagy in hematological malignancies [358,359,360] and solid tumors [361,362]. This evidence concerns the gene AKT1 and hematologic disorder.