Wang et al. (2006) highlighted the importance of this pathway in NHL by the genotyping of 13 single nucleotide polymorphism (SNPs) in 10 genes of the oxidative stress pathway including AKR1A1, AKR1C1, CYBA, GPX, MPO, NOS2A, NOS3, OGG1, PPARG and SOD2. This evidence concerns the gene AKR1A1 and non-Hodgkin lymphoma.