Subsequently, Lan et al. (2007) analyzed 10 candidate genes from oxidative stress pathway (AKR1A, AKR1C1, AKR1C3, CYBA, GPX1, MPO, NOS2A, NOS3, OGG1 and SOD2) in a cohort of female patients and identified 14 SNPs within the NOX, AKR1A1 and CYBA genes significantly associated with the risk of developing NHL [313]. Here, AKR1A1 is linked to non-Hodgkin lymphoma.