Sánchez-Lopez et al. (2020) showed that the activation of p-62-Nrf2 pathway, dependent on NF-kB plays a key role in the survival and drug resistance in CLL cells with high levels of ROR 1, a tyrosine kinase receptor associated with a poor prognosis [249]. The gene discussed is NFE2L2; the disease is B-cell chronic lymphocytic leukemia.