AKT1 and cancer: Agents like 3-methyladenine (3-MA), wortmannin, CQ, and HCQ have demonstrated promising effects in hematological malignancies and solid tumors affecting cancer cell viability, whereas wortmannin has shown to inhibit autophagy independently of nutrient availability and promote apoptosis by downregulating proliferative pathways (PI3K/Akt and NF-kappaB) [338,343,344].