While it is unclear how much the human colon-derived cancer cell line would represent the situation in vivo, it is noteworthy that the changes observed in ACE2 and TMPRSS2 in ulcerative colitis patients matched the changes we observed in inflamed Caco-2/TC7 cells [43], suggesting the potential of Caco-2/TC7 cells as a preliminary model to assess gut-related functions in vitro. This evidence concerns the gene TMPRSS2 and cancer.