NLRP3 and liver dysplastic nodule: Significantly elevated circulating glucose levels in patients with DN, on the one hand, can activate the NLR family pyrin domain containing 3 (NLRP3) inflammasome to induce pancreatic islet secretion of pro-inflammatory cytokines [18,19], which promotes the recruitment of monocytes and their differentiation into pro-inflammatory macrophages [20], and thus induces inflammatory responses [21].