Yi Tan et al. demonstrated that 3-nitrotyrosine accumulation and ERK phosphorylation were significantly increased in the hearts of streptozotocin-induced diabetic mice and diabetic patients with a significant decrease in NRF2 expression and that ERK acts as a negative regulator of glucose uptake by mediating the inhibition of NRF2 activity leading to OS-induced insulin resistance [51]. This evidence concerns the gene NFE2L2 and Insulin resistance.