The produced ROS leads to activation of the NLRP3 inflammasome, resulting in activation of caspase-1, cleavage of pro-IL-1β and pro-IL-18, and the production of active forms of IL-1β and IL-18, which increase the inflammatory response, fibrosis, and vascular remodeling in hypertension [181,182]. The gene discussed is NLRP3; the disease is hypertensive disorder.