5 cases (8.6%) of ADRs occurred in the simnotrelvir/ritonavir group, including 1 case (1.7%) of elevated creatinine, 2 cases (3.4%) of mildly elevated aminotransferase (ALT < 2 times ULN), 1 case (1.7%) of hypertriglyceridemia, and 1 case (1.7%) of hyperuricemia. This evidence concerns the gene GPT and hypertriglyceridemia.