MTOR and colorectal cancer: This drives uncontrolled cell proliferation, for example, via the RAF‐MEK‐ERK pathway, the Ral‐GEF pathway, and the PI3K‐AKT‐mTOR pathway.[31] For instance, KRasG12C is common in lung cancer and KRasG12D in colorectal cancer and pancreatic cancer.[30] All KRas isoforms have a conserved GTP‐binding pocket that could be theoretically targeted with conventional inhibitors.