For example, 11q23.2 (mapped gene: NCAM1/DRD2) and 18q12.2 (mapped gene: CELF4) is widely highlighted between neuroticism-IBS and neuroticism-GERD, and we found that 16q12.1 (mapped gene: NKD1/ZNF423/NOD2) and 2q37.1 (mapped gene: ATG16L1/SP140) are only highlighted in neuroticism/depressed-CD. The gene discussed is NOD2; the disease is irritable bowel syndrome.