Specifically, IL-18 levels exhibited a statistically suggestive causal effect on female infertility associated with cervical, vaginal, other or unspecified origin (OR: 0.91; 95% CI: 0.85–0.98; P = 9.38 × 10−3), as observed using the multivariable IVW method (OR: 0.92; 95% CI: 0.86–0.98; P = 1.40 × 10−2). The gene discussed is IL18; the disease is female infertility.