BDNF and bipolar disorder: In clinical settings, a study by Schuch et al. [202] demonstrated that a single session of maximal AE (participants underwent a maximal aerobic test on a bicycle ergometer, starting with a 5-min warm-up, initial load of 75 W for men and 50 W for women, increasing by 25 W every 60 s until test completion) resulted in significantly higher serum BDNF levels in bipolar disorder participants compared to healthy controls.