reported a case of a metastatic squamous cell carcinoma patient who developed positive anti-SS-A/Ro antibodies after receiving Cemiplimab treatment and was diagnosed with SCLE and immune-related hepatitis (21).In a large retrospective study of 4,487 cancer patients, 8 cases of ICI-induced SCLE were reported, with 2 cases attributed to Nivolumab (27). Here, CALR is linked to squamous cell carcinoma.