Multiple ligands have been identified that bind HVEM, one of which, LIGHT (homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes), has been identified as an important co-stimulatory molecule implicated in driving inflammatory diseases such as asthma (15–17). This evidence concerns the gene TNFSF14 and asthma.