Firstly, while our cell-based complementation model provides valuable preliminary insights into the role of the ADGRG6-mutant p53 signaling axis in regulating immune-related markers such as CD274, CD44, ITGB6, and LGALS9 in PAAD cells, it is essential to establish a mouse model with intact immune function to conduct relevant immunological experiments, which is crucial for confirming the role of the ADGRG6-mutant p53 axis in promoting immune escape in PAAD. This evidence concerns the gene CD44 and pancreatic adenocarcinoma.