Compared to the human pancreatic duct epithelial cell line hTERT-HPNE, both the mRNA and protein expression levels of ADGRG6 were significantly upregulated in all the five PAAD cell lines, including AsPC-1, BxPC-3, MIAPaca-2, CFPAC-1, and PANC-1 (Figures 7A, B). The gene discussed is ADGRG6; the disease is pancreatic adenocarcinoma.