BRCA1 and breast cancer: Although the summary guideline publications (Panay et al., 2024a, 2024b, 2025) do not address this issue in detail, the section of the full guideline ‘Risk of breast cancer in women with POI’ does address this complex topic, citing the same publications, which indicate a 30–40% lower risk of breast cancer in women with menopause before age 40 years (Collaborative Group on Hormonal Factors in Breast Cancer, 2012; Wu et al., 2014) and in those with POI secondary to risk-reducing bilateral oophorectomy for BRCA1/2 gene carriers (Rebbeck et al., 2009).