AKT1 and neuroblastoma: Furthermore, lactate secretion and HK3-mediated histone lactylation within NB cells have been shown to facilitate the recruitment and polarization of M2-like macrophages via the PI3K/AKT-CXCL14 axis (Figure 3), thereby contributing to the establishment of a tumor-promoting microenvironment and further accelerating NB progression (Wu et al., 2024a) (Table 2).