Conversely, in another study, Watanabe et al., revealed that ERAP1 modulates VEGF-induced angiogenesis and endothelial cell migration in human endometrial carcinoma by controlling the renin-angiotensin system (RAS) through a dose-dependent cleavage of Angiotensin II (Ang II) (Watanabe et al., 2003). Here, ERAP1 is linked to endometrial carcinoma.