ERAP1 and type 1 diabetes mellitus: In particular, by investigating the role of ERAP1 in the aetiopathogenesis of type 1 diabetes in human β-cells, the authors demonstrated that IRE1α inhibition correlates with the upregulation of miR-17, which negatively affects ERAP1 expression via direct interaction with its 3′-UTR region, ultimately reducing pre-pro-insulin processing.