We observed a decrease in the expression of miR‐130a‐5p in liver cancer cells transfected with the NS3 protein compared to nontransfected cells (Figure 4G; Figure S2D). Furthermore, anti‐miR‐130a‐5p could reverse the increase in miR‐130a‐5p expression induced by sh‐circ_0001175#1 (Figure 4H; Figure S2E). This evidence concerns the gene KRAS and liver cancer.