TP53 and colonic neoplasm: Similarly, Tazawa et al. transfected miR-34a into human colon cancer HCT116 cells, RKO cells, and p53-mutated SW480 cells and found that the volume of transfected cells increased and that cells showed signs of aging and staining with the SA-β-gal, indicating that miR-34a can induce cellular senescence [44].