High expression of SNHG1 in patients with colorectal cancer can interact with EZH2 to regulate histone methylation of Krüppel-like factor 2 (KLF2) and cyclin-dependent kinase inhibitor 2B (CDKN2B) in the nucleus and affect the biological behavior of colorectal cancer cells [153]. The gene discussed is KLF2; the disease is colorectal cancer.