SNCA and Lewy body dementia: The aggregation of α-synuclein is a key pathological hallmark in Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies (DLB).1-4 α-Synuclein is thought to aggregate from its native intrinsically disordered monomeric form, undergoing a profound structural transition through an α-helical structure to a β-sheet-rich filamentous configuration.5,6 This process leads to the formation of toxic oligomers and protofibrils and fibrils, which ultimately mature to form neuronal cytoplasmic inclusions termed ‘Lewy bodies’.7