SNCA and Parkinson disease: First, extracellular α-synuclein oligomers may bind to lipid rafts, which are cholesterol- and sphingomyelin-rich membrane domains involved in membrane fluidity and signalling.71 As α-synuclein specifically associates with lipid rafts, it may affect various signalling pathways linked to cellular death.72,73 For instance, the A30P mutation linked to Parkinson's disease disrupts α-synuclein interaction with lipid rafts,72 a critical process for its synaptic localization.