Gene polymorphisms of PAX9 rs2073247 (TT vs CC, CT + TT vs CC) and PAX9 rs2073244 (GG vs AA, AG vs AA, AG + GG vs AA) may increase the risk of non-syndromic hypodontia, and the susceptibility is more obvious in Caucasians and Hungarians. Here, PAX9 is linked to Hypodontia.