DNM1 and Alzheimer disease: GS identified a heterozygous deep intronic VUS in the MANE (Matched Annotation from the NCBI and EMBL-EBI) transcript of DNM1, associated with AD “developmental and epileptic encephalopathy 31A (OMIM: 616346).” However, this variant is close to an exon in the brain-specific transcript (NM_001288737.2) that is more relevant to this disease than the MANE transcript [39].