In squamous cell carcinoma tumor- bearing BALB/C mice treated with DaRT or inert seeds in combination with anti-PD-1 or IgG control antibody, the authors found that combination of DaRT with anti-PD-1 yielded to tumor growth delays and induced CD3 and CD8 lymphocytes infiltration, while reducing splenic polymorphonuclear myeloid derived suppressor cells more than immunotherapy alone. This evidence concerns the gene CD8A and neoplasm.