CD8A and squamous cell carcinoma: In squamous cell carcinoma tumor- bearing BALB/C mice treated with DaRT or inert seeds in combination with anti-PD-1 or IgG control antibody, the authors found that combination of DaRT with anti-PD-1 yielded to tumor growth delays and induced CD3 and CD8 lymphocytes infiltration, while reducing splenic polymorphonuclear myeloid derived suppressor cells more than immunotherapy alone.