Helminth-induced T-helper 2 (Th2) and regulatory T-cell (Treg) responses may contribute to depressed M. tuberculosis-specific Th1 responses.1 Interleukin 10 (IL-10) and transforming growth factor-beta (TGF-β) cytokine production during chronic helminth infection may also mediate antigen-specific T-cell hypo-responsiveness, including through impaired signal transduction.2 This evidence concerns the gene IL10 and helminthiasis.