In this study, we describe the design of a conjugate formed by a small interfering RNA (siRNA) for CEBPB mRNA transcript (siCEBPB) and a TfR RNA aptamer and evaluate its activity in vitro and in vivo, namely, in murine models of primary cirrhotic HCC and PDAC with liver metastasis. The gene discussed is TFRC; the disease is hepatocellular carcinoma.