Thus far, stereotactic body radiation therapy (24 Gy in three fractions and 50 Gy in four fractions) has often been used in studies evaluating the abscopal effect in metastatic NSCLC.10, 11, 12,15, 16, 17 In murine breast and colon carcinoma models, in combination with CTLA-4 blockade, fractionated local radiotherapy of 24 Gy in three fractions was more effective than 30 Gy in five fractions for induction of the abscopal effect, associated with higher IFN-γ expression by T cells.28 This evidence concerns the gene CTLA4 and colon carcinoma.