While our data excludes dominant monogenetic inheritance [31], recent findings of mosaic BRCA1 epimutations among patients from families with aggregation of breast/ovarian cancer not harboring germline variants [80] and a study reporting cases of BRCA1 normal tissue epimutation covariance between mothers and daughters [73] open the possibility of multifactorial inheritance or more complex recombination events as well as potential roles of exogenous or endogenous factors in pregnancy [63]. Here, BRCA1 is linked to ovarian carcinoma.