NLRP12 and NLRP12-associated hereditary periodic fever syndrome: In humans, mutations in NLRP12 have been linked to familial cold autoinflammatory syndrome 2 (FCAS2, OMIM #611762), which is characterized by recurrent, cold-induced episodes of fever associated with various systemic symptoms, including urticaria, headache, myalgia, arthralgia, and joint swelling [27–33].