Pancreatic manifestations were reported in four of the included studies [37, 42, 63, 68, 69], of which nine modifier genes were associated with pancreatic disease severity (SLC, PRSS1, PRSS2, SPINK1, CTRC, CASR, CTSB, KRT8, and ADRβ2). The gene discussed is PRSS1; the disease is pancreas disorder.